Analgesic and antidysuric effects of phenazopyridine in the treatment of acute uncomplicated cystitis: results of a 3-year study.

Introduction. Currently, there is a renaissance of phenazopyridine in world urology. The aim this work was to study the analgesic and antidysuric effects phenazopyridine, as well evaluate efficacy tolerability combination with fosfomycin for treatment acute uncomplicated cystitis women working age. Materials methods. In 2020–2022 multicenter randomized open conducted. This involved 224 aged 18 60 years cystitis. They were into two groups 112 people each. first group, patients received oral (Urinalgin F, earlier Fenazalgin) 200 mg 3 times day 2 days (total dose 1200 mg) trometamol (Monural) at g once. 2nd orally once drotaverine hydrochloride (No-spa) 80 days. visual analogue scale (VAS) pain, assessment symptoms according ACSS scale, urinalysis by microscopy, bacteriological examination urine used. results evaluated after 6, 12, 24 48 hours, 6 Results. 1st strong uroanalgesic effect revealed. According VAS, severity pain decreased from initial 7.3±0.5 points hours 3.7±0.4 points, 12 1.6 0.4 disappeared all patients. sum characteristic on 12.2±0.5 2.1±0.2 days, 0.27±0.04 indicators, less pronounced symptomatic obtained relief dysuria. combined turned out be more effective than hydrochloride: 97.3% recovered, efficiency 96.8%, leukocyturia an date, 30% reduced time. An undesirable (nausea) detected 1 (0.9%) patient. Сonclusion. Phenazopyridine has safe agent antibiotic improves cystitis, clinical 96.8%.